Аутори:
1. Dijana Jelić, Republic of Srpska, Bosnia and Herzegovina
2. Irena Kasagić-Vujanović, Republic of Srpska, Bosnia and Herzegovina
3. Vesna Antunović, Медицински факултет Бања Лука , Republic of Srpska, Bosnia and Herzegovina
4. Saida Fazlagić, Republic of Srpska, Bosnia and Herzegovina

Апстракт:
Ambroxol hydrochloride (AMB), (1s,4s)-4-((2-amino-3,5-dibromocyclohexyl)methylamino) cyclohexanol hydrochloride, is semi - synthetic derivative of vasicine obtained from Indian shrub Adhatoda vasica. In presented researche study, the focus was on stability of ambroxol hydrochloride (AMB), which is an active component in Flavamed® tablets. Using HPLC method combined with chemical kinetics we gave explanation on degradation and kinetics of AMB in commercial tablets. Degradation process was observed in neutral medium (water), at three different temperature: 25°C, 45°C and 70°C. All the relevant parameters, concerning stability of a drug, such as constant rate (k), activation energy (Ea), reaction order (n) and half-time (t1/2) were calculated. Obtained data are very important for the development of stable and safe drug product. Acknowledgements: This investigation is supported through the project 19/6-020/961-169/14financed by Ministry of Science and Technology of Republic of Srpska.

Кључне речи:
Key words: stability of drug, HPLC, ambroxol hydrochloride, kinetics

Тематска област:
СИМПОЗИЈУМ Ц - Вода

Датум пријаве сажетка:
30.06.2016.

Конференцијa:
Contemporary Materials 2016 - Савремени Материјали

Пријављени рад од аутора